The Science

What is in the bottle, why it is there, and what the evidence actually supports.

This page is not a claim that our products will do anything for you specifically. It is an account of the ingredients we chose and the reasoning behind each one, so that you can check the work. The studies we lean on are listed at the bottom.

Why form and dose matter more than the ingredient list

Two products can both say “magnesium” on the front. One uses magnesium oxide, which is cheap and poorly absorbed. The other uses chelated magnesium glycinate, which is bound to an amino acid, better tolerated, and gentler on the stomach. The label looks similar. The product is not.

The same is true of dose. An ingredient studied at 600mg and delivered at 50mg is decoration. This is what a proprietary blend conceals: not the recipe, but the amounts.

The four systems

Cellular energy — NAD+ and β-NMN

NAD+ is a coenzyme every cell uses in energy metabolism, and its levels decline measurably with age. β-Nicotinamide Mononucleotide (NMN) is a direct precursor the body uses in NAD+ synthesis, and it has become one of the most actively studied molecules in longevity research. A 2021 randomized, placebo-controlled trial published in Science found that ten weeks of oral NMN increased muscle insulin sensitivity in postmenopausal women with prediabetes [1]. Our NAD+ Booster delivers 500mg per capsule.

The honest position: this is an active area of research rather than a settled one. That trial had 25 participants. Larger and longer studies are still being written.

Stress response — KSM-66 Ashwagandha

Ashwagandha is an adaptogen with a long history in Ayurvedic practice and one of the better-studied botanicals in modern supplementation. In a 60-day randomized, double-blind, placebo-controlled trial, 600mg per day of KSM-66 root extract reduced perceived stress scores and serum cortisol compared with placebo [2]. We use KSM-66 at that same 600mg — the dose used in the research rather than a token amount.

Metabolic support — Berberine HCl

Berberine is a plant alkaloid that has been studied extensively for its role in glucose metabolism. It is one of the few botanicals with a substantial clinical literature behind it: a 2008 pilot trial in Metabolism reported effects on fasting glucose and HbA1c comparable to metformin over three months [3]. Our Metabolic delivers 790mg per serving.

If you take prescription medication, particularly anything affecting blood sugar, speak to your doctor before adding berberine.

Sleep and recovery — Reishi, L-Theanine, Valerian, Melatonin, Magnesium

Sleep is where repair happens, which makes it the least optional part of any longevity protocol. We offer two approaches deliberately. Sleep Ritual uses botanicals traditionally associated with calm — reishi, L-theanine, lemon balm, passionflower, valerian — without melatonin. Sleep Formula adds 2mg of melatonin for people who want direct support for their sleep-wake cycle. Calm supplies 275mg of elemental magnesium from 2,500mg of magnesium glycinate — the chelated form, which a randomized crossover trial found was absorbed better and tolerated better than magnesium oxide in people with impaired absorption [4].

Melatonin is a hormone, not a vitamin. More is not better, and 2mg is a considered amount rather than the 10mg found in many products.

What we do not know

Nutritional science moves slowly and reverses itself often. Some of what is promising today will look naive in ten years. Individual response varies enormously, and no supplement compensates for poor sleep, no movement, or a bad diet.

We would rather say that plainly than pretend otherwise.

Manufacturing

All Nuvori products are manufactured in a cGMP-registered facility in the United States. cGMP refers to Current Good Manufacturing Practice, the FDA framework covering facility conditions, process controls, and record-keeping. The Supplement Facts panel for every product is published as the second image on its page.

References

  1. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224–1229. PMID 33888596
  2. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255–262. PMID 23439798
  3. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712–717. PMID 18442638
  4. Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN J Parenter Enteral Nutr. 1994;18(5):430–435. PMID 7815675

These studies examined the ingredients, not Nuvori products, and several were conducted in specific clinical populations. They are cited so you can read the evidence yourself, not as claims about what our products will do for you.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before beginning any supplement, particularly if you are pregnant or nursing, taking medication, or managing a health condition.